Combination Therapy in Aesthetics: Why Strategic Layering is Redefining Facial Rejuvenation
July 18, 2025
Discover how a layered approach to aesthetic combination therapy creates personalized results patients love and helps your practice stand out.
The New Era of Aesthetic Rejuvenation
Today’s aesthetic patients seek subtle, natural-looking
results that last and feel tailored to their unique anatomy. As demand grows
for personalized, regenerative treatments, combination therapy has evolved from
a trend into a clinical standard.
Strategic layering, the intentional sequencing of synergistic treatments, is
redefining how practitioners approach facial rejuvenation. It’s setting new
benchmarks for patient satisfaction, clinical outcomes, and practice growth.
What is Combination Therapy?
In aesthetic medicine, combination therapy refers to the
integration of complementary modalities, such as injectables, regenerative
biologics, and energy-based devices, into a single, cohesive treatment plan.
When layered with precision, these treatments don’t simply add benefits; they
amplify each other’s effects. The result? Enhanced collagen remodeling
accelerated tissue regeneration, and more natural, multidimensional outcomes
that single treatments alone often can’t achieve.
Why More Aesthetic Practitioners Are Embracing the Layered Approach
Treat More in One Session
Combination therapy targets multiple concerns in a single visit, reducing the need for multiple appointments and making each session more efficient for both patient and provider
Deliver Faster, Visible Results
By targeting multiple skin layers at once, combination therapy accelerates collagen and delivers faster, visible results
Increase Revenue per Patient
Bundled treatment plans naturally increase average spend per visit while reducing scheduling gaps, leading to higher monthly revenue
Top Combination Therapies Every Practitioner Should Know
Microneedling + EZPRF (Platelet-Rich Fibrin)
Indication: Under-eye circles, fine lines, melasma, pigmentation, and dull skin. This synergistic duo targets both the epidermis and dermis for enhanced skin regeneration.
Microneedling creates micro-injuries that stimulate collagen production and improve skin permeability.
EZPRF delivers growth factors, platelets, leukocytes, and a fibrin matrix that supports tissue healing and rejuvenation.
Clinical benefits:
Brighter, more even skin tone
Smoother texture and visible glow
Improved under-eye rejuvenation
Enhances radiance and under-eye brightness
EZPRF (Platelet-Rich Fibrin) +
Fractional Laser (Topical Application Post-Treatment)
Indication: Post-procedural recovery following fractional CO₂, Erbium, or RF.
This combination enhances epidermal healing and improves patient comfort following ablative or non-ablative laser treatments. ezPRF post-treatment reduces inflammation and accelerates tissue regeneration, while minimizing downtime and improving results.
Clinical Benefits:
Decreases redness and sensitivity
Speeds up skin recovery
Improves the results of fractional lasers
Enhances final texture, tone, and clarity
EZPRF (Platelet-rich fibrin)
+ EZGEL (Bio-stimulating gel)
Indication: Tear troughs, volume loss, temple hollowing, under-eye pigmentation, and hair restoration.
This combination enhances epidermal healing and improves patient comfort following ablative or non-ablative laser treatments. ezPRF post-treatment reduces inflammation and accelerates tissue regeneration, while minimizing downtime and improving results.
Clinical Benefits:
Decreases redness and sensitivity
Speeds up skin recovery
Improves the results of fractional lasers
Enhances final texture, tone, and clarity
The Art of Reversal ® by Amy Lynn, RN, CANS
Ultrasound Guided Filler Dissolve + EZGEL PRF Volume Replenishment
What is The Art of Reversal®?
It’s an innovative injectable treatment developed by Amy Lynn, RN, CANS, designed to address less-than-ideal outcomes from hyaluronic acid dermal fillers, such as overfilling or “filler fatigue.”
It’s called Reversal because the protocol combines ultrasound-guided hyaluronidase to dissolve unwanted filler with immediate replenishment using 100% natural EZGEL PRF, restoring volume, improving tissue quality, and supporting long-term regeneration.
Why is EZGEL PRF Ideal Follow-Up Filler Dissolving?
When hyaluronic acid fillers are reversed, patients are often left with temporary volume loss, tissue dehydration, or laxity. ezGEL PRF offers a smarter, regenerative solution to restore balance and support long-term skin health.
Benefits of layering EZGEL after dissolving HA filler
100% natural autologous volume replacement
Immediate and progressive tissue regeneration helps restore youthful structure while improving skin integrity over time
Reduces laxity and post-dissolving dehydration counteracts the deflation phase associated with hyaluronidase
Improves lymphatic flow and skin quality enhances overall tone, circulation, and facial harmony
Summer Tip from Dr. Karimi
“Microneedling combined with regenerative growth factors like ezPRF is a powerful option during summer. It’s less restrictive when it comes to sun exposure, compared to other treatments like fractional lasers; making it a safe, effective choice for in-season skin rejuvenation and maintaining a healthy glow.”
Combination Therapy: Wow-Results
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