Clinical study breakthrough: EZGEL PRF delivers proven results for nasolabial folds rejuvenation.
The evidence is in—EZGEL’s natural approach to volume restoration works!
May 22, 2025
For aesthetic practitioners seeking science-backed, natural rejuvenation solutions, a groundbreaking clinical study now provides definitive proof: EZGEL PRF significantly reduces moderate-to-severe nasolabial folds with progressive improvement over 24 weeks.
In today's market where patients increasingly demand both natural alternatives and proven outcomes, this peer-reviewed research represents a major advancement for practices looking to expand their regenerative aesthetic offerings.
Let's talk about the data
The recently published pilot study, "Effectiveness of an Autologous Filler in Patients with Moderate-to-Severe Nasolabial Folds," conducted by renowned researchers Angela Cong, LaRyel Waldon, Aurelio Aquila, Sharon Stewart PA-C, Amit Kochhar MD, FACS, and Kian Karimi MD, FACS, delivers compelling evidence of EZGEL's effectiveness as a bio-stimulating gel combining platelet-rich fibrin with heated albumin.
STUDY DESIGN DETAILS:
24-week clinical evaluation
of 15 subjects (14 women, 1 man) aged 32-63 with grade 3-4 nasolabial folds
Strategic injection protocol
with treatments at baseline, week 4, and week 16 into subcutaneous, subdermal, and periosteal planes
Advanced volumetric measurement
using Vectra® 3D Analysis Module and QuantifiCare® LifeViz Infinity imaging systems
Comprehensive
follow-up
at weeks 2, 6, 8, 20, and 24 with additional safety monitoring
Remarkable results confirmed
The clinical data provides compelling evidence of EZGEL'S performance:
Patient satisfaction (GAIS*)
This translates to an impressive 92.3% of patients experiencing visible improvement by Week 20. At the 24-week endpoint, patient satisfaction was exceptional:
46%
Very much improved
Very much improved
31%
Much improved
15%
Improved
8%
No change
Volume Enhancement
Peak volume increase occurred at week 16, with an average gain of 1.31 cc as measured by advanced 3D imaging providing visible, natural-looking contour restoration.
Statistical significance was confirmed with ANOVA (p = 0.032).
Comparison of volumetric measurements taken 12 weeks from baseline LifeViz® Infinity 3D viewer
Wrinkle severity reduction
WSRS scores decreased dramatically from a baseline average of 3.3 (moderate-severe) to 0.75 (mild) at the study conclusion, with progressive improvement observed after each treatment session.
Visual comparison of the nasolabial folds 20 week from baseline using Vectra® 3D Analysis Module (VAM)
Safety profile
Only one adverse event was reported (swelling after COVID-19 diagnosis), which resolved without complications confirming EZGEL's excellent safety profile as an autologous treatment.
The science behind EZGEL PRF
EZGEL harnesses the regenerative power of Platelet-Rich Fibrin (PRF) a 100% autologous bio-stimulant containing vital growth factors: PDGF, VEGF, TGF-β, EGF, and IGF-1.
EZGEL works through a dual-action mechanism:
Immediate volumization through the fibrin matrix and albumin combination
Long-term biostimulation via sustained release of growth factors that actively stimulate collagen production, accelerate cell turnover, and enhance skin firmness
What makes EZGEL unique in the market
The EZGEL System transforms standard PRF into an advanced bio-filler through proprietary technology:
EZMINISPIN Centrifuge - Precisely calibrated to maximize platelet concentration
EZHEAT - Advanced thermal processing system that optimizes the structure and stability of the PRF gel
Complete Clinical Kit for Practice Success
The EZGEL Kit includes specialized components designed for safety, efficiency, and optimal outcomes:
Heat-resistant, BPA-free syringes - Maintain structural integrity and safety during the thermal modification process
13mL PRF tubes - Yield sufficient material for complete EZGEL protocols from a single blood draw
Medical-grade safety - All components include sterility indicators, lot numbers, and expiration dates
Regulatory compliance - Packaging assembled in a regulated environment to ensure consistent quality
This comprehensive approach creates a natural gel that enables strategic placement in multiple planes (subcutaneous, subdermal, and periosteal), maximizing both immediate and progressive rejuvenation.
Unexpected bonus: beyond nasolabial folds treatment
One of the study's most intriguing findings was that some subjects reported a midface lifting effect despite treatment being limited to nasolabial folds. This suggests EZGEL offers collateral rejuvenation benefits through strategic placement providing practitioners with additional value beyond the targeted treatment area.
Why leading practitioners are choosing EZGEL?
As patient demands evolve toward natural, preventative aesthetic solutions, EZGEL provides practitioners with significant advantages:
The future of regenerative aesthetics is here
For practices seeking to differentiate in a competitive market, EZGEL represents more than just another treatment option it's a clinically validated advancement that supports the growing trend toward autologous solutions in aesthetic medicine.
THE STUDY DATA CONFIRMS THAT EZGEL DELIVERS:
Natural results through a completely bio-compatible approach
Measurable volume restoration with statistical significance
Progressive improvement that continues developing for months
High patient satisfaction with over 92% reporting visible improvement This opens exciting possibilities for combination protocols, such as PRF with threads or lasers, allowing practitioners to create fully customized treatment plans.
See the transformation for yourself
Ready to transform your practice with EZGEL?
Contact us today to learn more about bringing this clinically proven technology to your patients. Our team provides comprehensive support to ensure optimal results with EZGEL's strategic injection protocol.
EZGEL PRF: Clinically proven. Naturally effective
*GAIS: Global Aesthetic Improvement Scale - A standardized measurement tool used to assess aesthetic outcomes based on before and after comparisons.