EZPRF vs EZGEL: Understand the Difference, Choose the Right Treatment Every Time
June 25, 2025
Curious about the difference between EZPRF and EZGEL? Whether you specialize in natural regenerative treatments or are exploring alternatives to synthetic dermal fillers, understanding how these two autologous solutions work is essential to delivering better patient outcomes and improving practice profitability.
Both EZPRF and EZGEL harness the body’s natural healing mechanisms but they serve distinct purposes. In this article, we break down the key differences, clinical applications, and treatment strategies for each one, so you can choose the right solution for every aesthetic indication.
What is EZPRF?
EZPRF (Platelet-Rich Fibrin) is the most advanced form of autologous blood concentrate available today. It’s derived from the patient’s own blood and processed using a low-speed centrifugation system, which preserves a higher concentration of platelets, white blood cells, and mesenchymal stem cells. Unlike PRP (Platelet-Rich Plasma), EZPRF contains no anticoagulants and forms a natural fibrin matrix for slow growth factor release.
Why Aesthetic Providers Use ezPRF
ezPRF Best Use Cases
Skin glow and texture refinement
Under-eye pigmentation and crepiness
In combination with Microneedling treatment
Hair restoration (scalp injections)
Post-laser recovery
Non-volume skin revitalization protocols
Clinical takeaway: Use EZPRF when the goal is rejuvenation, not volume, especially in combination with energy-based devices or microneedling.
See EZPRF Transformation
Hair Restoration
Eugenia Xiao DNP, AGPCNP-BC | 1 sessions of ezPRF
Brown Spots, Tear Troughs discoloration
Anil Rajani, MD | 2 sessions of ezPRF Combined with microneedling
What Is EZGEL?
EZGEL is a 100% natural, autologous bio-filler created by transforming EZPRF into a gel-like matrix using a controlled heating and cooling process. This albumin serum creates a viscous, injectable gel that provides volume and regenerative stimulation.
It combines the regenerative power of EZPRF with a filler-like consistency making it an ideal natural alternative to synthetic fillers.
Why Aesthetic Providers Use ezGEL
ezGEL Best Use Cases
Tear troughs with hollowing
Midface volume loss and temple deflation
Lips, chin, marionette lines, nasolabial folds
Neck rejuvenation
Clinical takeaway: Choose EZGEL when your patient needs volume restoration plus deep regenerative longevity.
See EZGEL Transformation
Tear trough
Tatum Prince, RN | 2 session of ezGEL 8 weeks apart
Nasolabial Folds
Dr. Bruno Bioulac | 1 session of ezGEL
Side-by-side Comparison: EZPRF VS. EZGEL
Why Top Injectors Combine EZPRF + EZGEL
EZPRF and EZGEL are not interchangeable; they are complementary tools. Together, they support multi-layer regenerative treatment strategies:
- EZPRF activates superficial skin cells, delivers bio-stimulation, and boosts glow
- EZGEL provides deep structural support and bio-stimulation
Combining both in the same treatment plan allows providers to:
- Address multiple concerns in one session
- Improve treatment longevity
- Increase patient satisfaction and lifetime value
- Offer a fully autologous, customizable regenerative experience
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