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ezPRF vs ezGEL: Understand the Difference, Choose the Right Treatment Every Time

EZPRF vs EZGEL: Understand the Difference, Choose the Right Treatment Every Time

June 25, 2025


Curious about the difference between  EZPRF and EZGEL? Whether you specialize in natural regenerative treatments or  are exploring alternatives to synthetic dermal fillers, understanding how these two autologous solutions work is essential to delivering better patient outcomes and improving practice profitability.

Both EZPRF and EZGEL harness the body’s natural healing mechanisms but they serve distinct purposes. In this article, we break down the key differences, clinical applications, and treatment strategies for each one, so you can choose the right solution for every aesthetic indication.

What is EZPRF?

EZPRF (Platelet-Rich Fibrin) is the most advanced form of autologous blood concentrate available today. It’s derived from the patient’s own blood and processed using a low-speed centrifugation system, which preserves a higher concentration of platelets, white blood cells, and mesenchymal stem cells. Unlike PRP (Platelet-Rich Plasma),  EZPRF contains no anticoagulants and forms a natural fibrin matrix for slow growth factor release.

Why Aesthetic Providers Use ezPRF


ezPRF Best Use Cases 

 Skin glow and texture refinement

 Under-eye pigmentation and crepiness

 In combination with Microneedling treatment

 Hair restoration (scalp injections)

 Post-laser recovery

 Non-volume skin revitalization protocols

Clinical takeaway: Use EZPRF when the goal is rejuvenation, not volume, especially in combination with energy-based devices or microneedling.

See EZPRF Transformation

Hair Restoration

Eugenia Xiao DNP, AGPCNP-BC | 1 sessions of ezPRF

Brown Spots, Tear Troughs discoloration

Anil Rajani, MD | 2 sessions of ezPRF Combined with microneedling     

What Is EZGEL?

 EZGEL is a 100% natural, autologous bio-filler created by transforming EZPRF into a gel-like matrix using a controlled heating and cooling process.  This albumin serum creates a viscous, injectable gel that provides volume and regenerative stimulation.

It combines the regenerative power of EZPRF with a filler-like consistency making it an ideal natural alternative to synthetic fillers.

 Why Aesthetic Providers Use ezGEL


 ezGEL Best Use Cases

 Tear troughs with hollowing 

 Midface volume loss and temple deflation 

 Lips, chin, marionette lines, nasolabial folds 

 Neck rejuvenation

Clinical takeaway: Choose EZGEL when your patient needs volume restoration plus deep regenerative longevity.

See EZGEL Transformation

Tear trough

Tatum Prince, RN | 2 session of ezGEL 8 weeks apart

Nasolabial Folds

Dr. Bruno Bioulac | 1 session of ezGEL

Side-by-side Comparison: EZPRF VS. EZGEL 


Why Top Injectors Combine EZPRF + EZGEL 

EZPRF and EZGEL are not interchangeable; they are complementary tools. Together, they support multi-layer regenerative treatment strategies:

  • EZPRF activates superficial skin cells, delivers bio-stimulation, and boosts glow
  • EZGEL provides deep structural support and bio-stimulation

Combining both in the same treatment plan allows providers to:

  • Address multiple concerns in one session
  • Improve treatment longevity
  • Increase patient satisfaction and lifetime value
  • Offer a fully autologous, customizable regenerative experience

 Ready to Offer Natural Regeneration in Your Practice?

Contact us to request your EZPRFEZGEL consultation

 We’re here to help you create safer, longer-lasting, and more natural aesthetic outcomes.  

CosmoFrance 25 June, 2025
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