How Albumin PRF (EZGEL) Is Redefining Aesthetic Outcomes
January 27, 2026
The latest issue of Modern Aesthetics highlights a major shift in how regenerative aesthetics is approached: Albumin Platelet-Rich Fibrin (aPRF/ EZGEL), a 100% autologous gel that moves beyond temporary correction, promoting true tissue regeneration
As patient demand grows for natural, biologically-driven solutions, EZGEL (albumin PRF) emerges as a science-backed alternative to traditional fillers. By harnessing the body’s own growth factors, EZGEL restores volume, improves tissue quality, and stimulates long-term collagen production.
Read full article: Harnessing PRF and Albumin , The science behind aPRF and its role in regenerative aesthetics
Clinical Evidence: Nasolabial Fold Study
The Modern Aesthetics article demonstrated the effectiveness and safety of EZGEL by referencing a prospective clinical study by our medical director Kian Karimi MD, FACS. The study evaluated patients with moderate-to-severe nasolabial folds and showed meaningful aesthetic improvement:
48%
rated “very much improved”
Progressive
reduction in wrinkle severity observed after each session
31%
rated
“much improved”
No
serious adverse events
These findings confirm EZGEL's safety and regenerative efficacy, delivering natural volume restoration with continued improvement over weeks.
Beyond Standalone Regeneration: EZGEL in Advanced Correction Strategies
Beyond its use as a primary regenerative injectable, Modern Aesthetics also highlights
EZGEL's growing role in advanced correction and reversal protocols, where tissue preservation is critical.
The Art of Reversal®: Regeneration Meets Precision
Developed by Amy Lynn, RN, CANS, The Art of Reversal® protocol redefines filler correction by combining precise hyaluronidase-based dissolution with immediate regenerative restoration using
EZGEL.
Unlike traditional approaches that remove unwanted filler without supporting tissue recovery, this dual-action protocol:
- Targeted Filler Dissolution: Ultrasound-guided injections ensure only residual filler is treated.
- Immediate Regenerative Support: EZGEL scaffolds repair, stimulates collagen, and restores natural volume.
- Minimized Recovery: Reduced inflammation and accelerated healing.
- Tissue Integrity Preservation: Autologous biologics maintain dermal health even after repeated filler corrections.
PRF in Advanced Regenerative Treatments
As noted in Modern Aesthetics, PRF is increasingly used alongside fat grafting and bio-stimulants to enhance tissue retention, vascularization, and overall regenerative outcomes. It's fully autologous fibrin matrix supports sustained growth factor release, making it a biologically aligned alternative to earlier platelet concentrates. These combination approaches reflect a shift toward regenerative treatments that prioritize tissue quality and long-term results over temporary correction.
To learn more about EZGEL, its clinical applications, and how it can be integrated into your regenerative protocols, connect with a CosmoFrance representative for personalized information and support.
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